The Loss of Multifractality in Migraines

Migraine headaches have been the bane of humanity for centuries, afflicting such notables as Ceasar, Pascal, Kant, Beethoven, Chopin, and Napoleon. However, its aetiology and pathomechanism have not to date been satisfactorily elucidated. Herein we demonstrate that the characteristics of the time series associated with cerebral blood flow (CBF) significantly differs between that of normal healthy individuals and migraineurs. Migraine is considered by many to be a functional neurological disorder in which CBF autoregulation failure may be responsible for the onset of symptoms. The results of our data analysis support this interpretation.